Figure 2
From: Early biomarkers and potential mediators of ventilation-induced lung injury in very preterm lambs
IL-1β, -6 and -8 mRNA levels following injurious ventilation. IL-1β, IL-6 and IL-8 mRNA levels (mean ± SEM) in preterm lamb lungs at 132 days of gestation resuscitated at birth using an injurious ventilation (IV) strategy for 15 minutes, then ventilated gently for 15–120 minutes. Values are expressed as a fold change relative to values in unventilated age-matched control fetuses (T = 0 values). IL-6 and IL-8 mRNA levels were significantly higher than the levels in unventilated control fetuses (p < 0.05) at all timepoints after the IV period. IL-1β mRNA levels were significantly higher than the levels in unventilated control fetuses at 15, 30 and 60 minutes after the IV period.