Figure 2
From: Antenatal and postnatal corticosteroid and resuscitation induced lung injury in preterm sheep
Cytokines and Early Growth Response Protein 1 mRNA in lung tissue. (A) IL-1β mRNA and (B) Monocyte chemotactic protein 1 (MCP-1) mRNA increased with the stretch injury and ventilation in all groups relative to unventilated controls. Il-1β and MCP-1 were decreased by Betamethasone (Beta) and Dexamethasone (Dex) compared to the Injury group. (C) The increase in IL-6 mRNA with ventilation was suppressed by Beta. (D) Egr-1 mRNA increased in the Injury and Cortisol groups. Cytokine mRNA was normalized to L32 mRNA (loading control). All values reported as fold increases compared with control animals, normalized to 1. *p < 0.05 vs Controls. t p < 0.05 vs Injury group