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Figure 6 | Respiratory Research

Figure 6

From: Secondhand smoke inhibits both Cl- and K+ conductances in normal human bronchial epithelial cells

Figure 6

SHS reduces apical membrane Cl - conductance. A) Representative current tracings (sham: open circles; SHS: shaded circles) demonstrating that nystatin-permeabilization of the basolateral membrane allows for a diffusive Cl current (ICl) that can be inhibited by GlyH-101, a blocker of CFTR channels. Note that addition of amiloride has no effect on current, confirming that the intracellular Na+ concentration was defined by the serosal bath solution. B) Normalized changes in ICl with forskolin and GlyH-101 (** p ≤ 0.01 by unpaired t-test).

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