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Figure 3 | Respiratory Research

Figure 3

From: Secondhand smoke inhibits both Cl- and K+ conductances in normal human bronchial epithelial cells

Figure 3

Inhibition of forskolin-stimulated Cl - secretion is time-dependent. A) Normalized change in ISC after forskolin stimulation is similar between sham (open circles) and SHS-exposed (shaded circles) HBECs at 3 min, but decreased at 10 and 60 min (* p ≤ 0.05 by unpaired t-test, n = 8 inserts, 2 donors and 17 inserts, 3 donors, respectively). Change in forskolin-stimulated ISC is further decreased in the SHS-exposed group at 180 min (*** p ≤ 0.001 by unpaired t-test, n = 19 inserts, 3 donors). Normalized ISC for sham-exposed HBECs remains 1 because each time-point is normalized independently. B) Normalized change in ISC after forskolin stimulation is still decreased after an overnight recovery period (*** p ≤ 0.001 by unpaired t-test, n = 12 inserts, 3 donors).

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