Figure 2
From: Secondhand smoke inhibits both Cl- and K+ conductances in normal human bronchial epithelial cells
SHS inhibits forskolin-stimulated Cl - secretion. A) Representative ISC tracing after 30 min sham (open circles) or SHS exposure (gray circles). Note that the decrease in forskolin-stimulated ISC in SHS-exposed HBECs is completely accounted for by a decrease in bumetanide sensitive ISC. B) Normalized changes in ISC with amiloride, forskolin, and bumetanide (** p < 0.01 and *** p < 0.001 by unpaired t-test, n = 32 inserts, 5 donors). C) Normalized changes in ISC with forskolin and CFTRinh-172 (** p < 0.01 and *** p < 0.001 by unpaired t-test, n = 6 filters, 2 donors).