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Table 3 Mean changes in desmosine and Isodesmoeine after two months of Tiotropium therapy

From: The effect of tiotropium therapy on markers of elastin degradation in COPD

BODY FLUID N LEVELS (mean ± SD) P VALUE
   AT BASELINE AT 2 MONTHS  
Plasma ng/ml 12 0.62 ± 0.12 0.43 ± 0.10 0.0037
Urine (free/total %) 12 45.96 ± 8.11 38.37 ± 4.43 0.0044
Sputum ng/ml 12 0.39 ± 0.26 0.13 ± 0.02 0.0035