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Figure 7 | Respiratory Research

Figure 7

From: Characterisation of the proximal airway squamous metaplasia induced by chronic tobacco smoke exposure in spontaneously hypertensive rats

Figure 7

Comparison of squamous metaplasia in human COPD and TS exposed SH rat lungs. Squamous metaplasia was identified in human COPD lung tissue (C, E) and 14 week TS exposed SH rat lungs (D, F) and compared to either non-squamous airways in COPD lung (A) or FA exposed SH rats (B). They were stained for p63 (A, B, E, F) and CK13 (C, D). In the control non-squamous airways from both human (A) and rat (B), p63 stained occasional flattened cells close to the basement matrix of proximal airways. Areas of squamous metaplasia were identified in both human (C) and rat (D) tissue by CK13 staining. In contrast to the extensive p63 staining seen in the rat tissue (F), the human tissue showed only sporadic cells scattered through out the squamous metaplasia (E).

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