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Figure 3 | Respiratory Research

Figure 3

From: Characterisation of the proximal airway squamous metaplasia induced by chronic tobacco smoke exposure in spontaneously hypertensive rats

Figure 3

Cellular turnover following TS exposure in SH rats. Antibodies to Ki67 (A-D) and cleaved caspase 3 (E, F) were used to determine the level of cell turnover following TS exposure. Areas of squamous metaplasia in both proximal (A) and distal (B) airways were strongly and extensively stained for Ki67 compared to FA controls (data not shown). Within the alveolar bed, the numbers of cells staining for Ki67 was increased after TS exposure (C) compared to the FA controls (D). Staining for cleaved capsase 3 showed a marginal increase in the numbers of cells staining following TS exposure (E, arrowheads) compared to FA controls (F, arrowhead). Staining was also seen in vesicles of alveolar macrophages (F, arrows). Magnification bar in B applies to panels A and B. Magnification bar in E applies to panels C-E.

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Respiratory Research

ISSN: 1465-993X

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