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Figure 2 | Respiratory Research

Figure 2

From: Characterisation of the proximal airway squamous metaplasia induced by chronic tobacco smoke exposure in spontaneously hypertensive rats

Figure 2

Morphology of TS induced changes in the lung parenchyma of SH rats. H&E stain for pathological assessment. FA exposed rats showed fibrinoid leakage from the alveolar bed (A, arrows) but minimal changes to resident cells. Following TS exposure for 14 week, there was evidence of an inflammatory infiltrate within perivascular/peribronchiolar regions (B, arrow). There was also fibrosis of blood vessels and the alveolar bed (C, arrows). Casts of the alveolar capillaries (C, inset, arrows) indicated remodelling of the microvascular network. Loss of connectivity was also seen (D, asterisks) within the alveolar bed.

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