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Table 7 Lung Lavage Cytokine Levels

From: Eosinophil and T cell markers predict functional decline in COPD patients

 

IL-1Ra

IL-2

IL-6

IL-8

IP-10

RANTES

MCP-1

Eotaxin

Rapid COPD

30.1(36.7)

27.4(43.2)

31.7(38.0)

32.7(23.9)

24.8(17.7)

28.0(28.1)

25.3(37.6)

30.6(34.3)

Stable COPD

9.0(22.3)

13.6(37.0)

20.6(38.2)

18.0(25.4)

15.8(17.6)

22.6(38.0)

8.3(23.4)

5.9(13.2)

Normal Controls

16.4(39.0)

27.5(51.3)

16.6(47.0)

38.2(36.3)

39.3(29.3)

6.6(18.6)

9.3(26.2)

0(0)

  1. n = 9 for rapid decliners, n = 11 for stable COPD subjects, n = 8 for normal controls
  2. Data is reported as mean ± standard error of measurement
  3. The standard error of measurement is in parentheses
  4. Lung lavage levels of 25 human cytokines were measured in stable COPD participants (n = 11), rapidly progressive COPD participants (n = 9) and normal controls (n = 8) using the Luminex 25-plex assay. Eight of these cytokines had detectable levels within our samples. Significant changes in cytokine levels between stable and rapid decliners were detected for eotaxin-1 (indicated in bold, p < 0.05). Parentheses indicate standard error of measurement.