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Table 5 Comparisons between Plasma Cytokine Levels in COPD.

From: Eosinophil and T cell markers predict functional decline in COPD patients

 

NORMALS (N = 11)

EMPHYSEMA (N = 27)

p value

IL-1β

151(55)

329(58)

NS

IL-1Ra

1665(589)

2933(575)

NS

IL-2*

27(11)

49(8)

NS

IL-2R*

511(162)

631(95)

NS

IL-4

21(9)

62(11)

<0.04

IL-5

9(4)

26(5)

<0.05

IL-6

47(17)

74(10)

NS

IL-7

37(16)

97(13)

<0.02

IL-8

10(2)

18(2)

<0.04

IL-10

78(52)

47(10)

NS

IL-12p40/p70

503(53)

590(60)

NS

IL-13

17(9)

33(9)

NS

IL-15

101(48)

171(26)

NS

IL-17

46(24)

107(20)

NS

TNF-α

69(22)

75(15)

NS

IFN-α

70(41)

264(43)

<0.02

IFN-γ

73(32)

158(26)

NS

GM-CSF

192(71)

423(59)

<0.04

MIP-1α

119(19)

192(20)

<0.05

MIP-1β

831(235)

1771(230)

<0.03

IP-10

60(12)

95(8)

<0.04

MIG

505(247)

819(120)

NS

EOTAXIN*

1043(237)

659(77)

=0.06

RANTES

30969(4420)

33527(3411)

NS

MCP-1

1931(158)

1776(98)

NS

  1. Plasma levels of 25 human cytokines were measured in COPD participants (n = 27) and age-matched normal controls (n = 11) using the Luminex 25-plex assay. Additional analyses for plasma IL-2, IL-2R and Eotaxin-1 were conducted on 6 rapid decliners and 17 stable COPD subjects. Significant changes in cytokine levels were found in nine of the examined cytokines (indicated in bold, p < 0.05). Parentheses indicate standard error of measurement.
  2. *N = 11 for normal controls and N = 50 for emphysema subjects
  3. Data is reported as mean ± standard error of measurement
  4. The standard error of measurement is in parentheses