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Figure 6 | Respiratory Research

Figure 6

From: Impaired immune responses in the lungs of aged mice following influenza infection

Figure 6

Chemokines. Several chemokines were determined in the lung supernatants of aged and adult mice infected with influenza virus. MIP-1β increased and peaked earlier in adult animals (black squares) (A). KC increased similarly in the lungs of adult (black circles) and aged (white squares) mice, however peaked earlier in adult animals (B). MCP-1 had a mild early peak in adult mice (black circles), while a higher delayed peak in aged animals (white squares) (C). There was a biphasic expression pattern of RANTES in adult mice (black circles) with a peak in concentrations at day 5 and 15 (D), while aged animals (white squares) had a very mild increase in this chemokine. The overall delayed production of chemokines correlated with delays in infiltration kinetics of innate and adaptive cells the lungs. The graphs represent cumulative results of two different experiments. The arithmetic mean (± SEM) concentration of 4-6 mice assayed at each time point was plotted. Stars indicate statistical difference between aged and naïve animals. *P < 0.05. **P < 0.01. ***P < 0.001.

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