From: Disparate oxidant gene expression of airway epithelium compared to alveolar macrophages in smokers
Category | Probe set ID | Gene symbol | Gene title | Nonsmoker % present2 | Healthy smoker % present | Smokers/nonsmokers (fold-change) | p value |
---|---|---|---|---|---|---|---|
Glutathione metabolism | 202275_at | G6PD | glucose-6-phosphate dehydrogenase | 42 | 77 | 1.78 | 0.015 |
 | 202923_s_at | GCLC | glutamate-cysteine ligase, catalytic subunit | 100 | 100 | 1.50 | 0.005 |
 | 202831_at | GPX2 | glutathione peroxidase 2 | 100 | 100 | 5.00 | < 0.001 |
 | 205770_at | GSR | glutathione reductase | 100 | 100 | 1.60 | 0.013 |
Redox balance | 210505_at | ADH7 | alcohol dehydrogenase 7, mu or sigma polypeptide | 100 | 100 | 5.37 | < 0.001 |
 | 201272_at | AKR1B1 | aldo-keto reductase family 1, member B1 | 100 | 100 | 1.72 | < 0.001 |
 | 209160_at | AKR1C3 | aldo-keto reductase family 1, member C3 | 100 | 100 | 2.53 | < 0.001 |
Catalase/SOD | No smoking responsive genes in this category in small airway epithelium | ||||||
Other oxidants scavengers | 202018_s_at | LTF | lactotransferrin | 100 | 87 | -3.16 | < 0.001 |
 | 212859_x_at | MT1E | metallothionein 1E | 100 | 100 | -1.75 | < 0.001 |
 | 213629_x_at | MT1F | metallothionein 1F | 100 | 100 | -2.00 | < 0.001 |
 | 208581_x_at | MT1X | metallothionein 1X | 100 | 100 | -1.56 | 0.002 |
 | 212185_x_at | MT2A | metallothionein 2A | 100 | 100 | -1.64 | 0.001 |
 | 201266_at | TXNRD1 | thioredoxin reductase 1 | 100 | 100 | 1.87 | < 0.001 |
Pentose phosphate cycle | 201118_at | PGD | phosphogluconate dehydrogenase | 100 | 100 | 1.66 | 0.008 |
 | 213093_at | PRKCA | protein kinase C, alpha | 100 | 100 | -1.52 | < 0.001 |
 | 201463_s_at | TALDO1 | transaldolase 1 | 100 | 100 | 1.61 | 0.001 |
 | 208699_x_at | TKT | transketolase | 100 | 100 | 1.79 | 0.008 |
Xenobiotic metabolism | 202437_s_at | CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | 32 | 97 | 25.41 | < 0.001 |
 | 206515_at | CYP4F3 | cytochrome P450, family 4, subfamily F, polypeptide 3 | 95 | 93 | 2.27 | 0.001 |
 | 206153_at | CYP4F11 | cytochrome P450, family 4, subfamily F, polypeptide 11 | 79 | 90 | 3.21 | 0.013 |
 | 227702_at | CYP4X1 | cytochrome P450, family 4, subfamily X, polypeptide 1 | 100 | 100 | -2.02 | < 0.001 |
 | 206424_at | CYP26A1 | cytochrome P450, family 26, subfamily A, polypeptide 1 | 37 | 63 | 2.05 | 0.045 |
Bilirubin related | No smoking responsive genes in this category in small airway epithelium | ||||||
Ascorbic acid related | No smoking responsive genes in this category in small airway epithelium | ||||||
Production of free radicals | No smoking responsive genes in this category in small airway epithelium |