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Table 2 Smoking Responsive Oxidant-related Gene Expression in the Small Airway Epithelium1

From: Disparate oxidant gene expression of airway epithelium compared to alveolar macrophages in smokers

Category

Probe set ID

Gene symbol

Gene title

Nonsmoker

% present2

Healthy smoker

% present

Smokers/nonsmokers (fold-change)

p value

Glutathione metabolism

202275_at

G6PD

glucose-6-phosphate dehydrogenase

42

77

1.78

0.015

 

202923_s_at

GCLC

glutamate-cysteine ligase, catalytic subunit

100

100

1.50

0.005

 

202831_at

GPX2

glutathione peroxidase 2

100

100

5.00

< 0.001

 

205770_at

GSR

glutathione reductase

100

100

1.60

0.013

Redox balance

210505_at

ADH7

alcohol dehydrogenase 7, mu or sigma polypeptide

100

100

5.37

< 0.001

 

201272_at

AKR1B1

aldo-keto reductase family 1, member B1

100

100

1.72

< 0.001

 

209160_at

AKR1C3

aldo-keto reductase family 1, member C3

100

100

2.53

< 0.001

Catalase/SOD

No smoking responsive genes in this category in small airway epithelium

Other oxidants scavengers

202018_s_at

LTF

lactotransferrin

100

87

-3.16

< 0.001

 

212859_x_at

MT1E

metallothionein 1E

100

100

-1.75

< 0.001

 

213629_x_at

MT1F

metallothionein 1F

100

100

-2.00

< 0.001

 

208581_x_at

MT1X

metallothionein 1X

100

100

-1.56

0.002

 

212185_x_at

MT2A

metallothionein 2A

100

100

-1.64

0.001

 

201266_at

TXNRD1

thioredoxin reductase 1

100

100

1.87

< 0.001

Pentose phosphate cycle

201118_at

PGD

phosphogluconate dehydrogenase

100

100

1.66

0.008

 

213093_at

PRKCA

protein kinase C, alpha

100

100

-1.52

< 0.001

 

201463_s_at

TALDO1

transaldolase 1

100

100

1.61

0.001

 

208699_x_at

TKT

transketolase

100

100

1.79

0.008

Xenobiotic metabolism

202437_s_at

CYP1B1

cytochrome P450, family 1, subfamily B, polypeptide 1

32

97

25.41

< 0.001

 

206515_at

CYP4F3

cytochrome P450, family 4, subfamily F, polypeptide 3

95

93

2.27

0.001

 

206153_at

CYP4F11

cytochrome P450, family 4, subfamily F, polypeptide 11

79

90

3.21

0.013

 

227702_at

CYP4X1

cytochrome P450, family 4, subfamily X, polypeptide 1

100

100

-2.02

< 0.001

 

206424_at

CYP26A1

cytochrome P450, family 26, subfamily A, polypeptide 1

37

63

2.05

0.045

Bilirubin related

No smoking responsive genes in this category in small airway epithelium

Ascorbic acid related

No smoking responsive genes in this category in small airway epithelium

Production of free radicals

No smoking responsive genes in this category in small airway epithelium

  1. 1 Smoking responsive genes defined as fold-change smokers compared to nonsmokers >1.5 and p value < 0.05 in genes expressed in >50% of either nonsmokers or smokers. Bold type represents differentially expressed genes in both small airway epithelium and alveolar macrophages (see Table 3).
  2. 2 % present refers to Affymetrix Detection Call of Present as a % of total numbers of healthy nonsmokers (n = 19) and healthy smokers (n = 30).