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Table 3 Summary of pharmacokinetic parameters in plasma for severe COPD patients

From: The bioavailability and airway clearance of the steroid component of budesonide/formoterol and salmeterol/fluticasone after inhaled administration in patients with COPD and healthy subjects: a randomized controlled trial

 

Treatment

n

Mean

SD/CV

Tmax (min)

Budesonide

24

15.5*

7.2*

 

Fluticasone

23

50.8*

25.4*

MRT (h)

Budesonide

24

4.41*

1.59*

 

Fluticasone

23

12.78*

4.58*

Cmax (μM)

Budesonide

24

1.08†

95.9†

 

Fluticasone

23

0.09†

37.9†

  1. Cmax = maximum concentration; CV = coefficient of variation; MRT = mean residence time; SD = standard deviation; Tmax = time to maximum concentration.
  2. * Arithmetic mean/SD; † Geometric mean/CV
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Respiratory Research

ISSN: 1465-993X

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