Figure 1

Obliterative bronchiolitis patients had more compact alveolar parenchyma than the controls. The structural changes in bronchioles were characterized by Gomori's trichrome staining. Panel (a) shows tissue from a lung-transplanted patient. The bronchiole has been obliterated with extra cellular matrix (ECM); the arrows show two neo-lumens. Scale bar: 100 μm; original magnification: 20×. Panels b and c show tissues in alveolar parenchyma from patients with thickened (b) and normal (c) alveolar parenchyma. Original magnification: 20×. Panel d shows changes in percentage tissue in alveolar parenchyma in the group of obliterative bronchiolitis patients. The amount of parenchyma was significantly greater in the obliterative bronchiolitis group than in the controls. Panel e represents the correlation between percentage area of the endothelial layer and percentage tissue in alveolar parenchyma (R = 0.6497; p < 0.05). Lung transplanted, closed circle; bone marrow transplanted, open circle; control, circle with dot.