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Table 2 LOCF-method vs. Completers/non-Completers analyses of VC, DLco, and CPI: changes between last measurement and base line

From: Lung function in idiopathic pulmonary fibrosis - extended analyses of the IFIGENIA trial

 

LOCF-method

Completers

Non-Completers

Change from baseline †

NAC

PLA

NAC

PLA

NAC

PLA

VC (l)

-0.057

-0.233

-0.062

-0.148

-0.207

-0.424

± SE

± 0.054

± 0.057

± 0.063

± 0.069

± 0.114

± 0.119

n =

71

68

55

51

16

17

p =

0.29

<0.0001

0.33

0.036

0.084

0.0017

VC (% pred.)

-0.830

-5.634

-1.245

-3.178

-2.849

-10.109

± SE

± 1.426

± 1.539

± 1.655

± 1.837

± 3.241

± 3.590

n =

71

68

55

51

16

17

p =

0.56

0.0004

0.434

0.087

0.39

0.0098

DLco (mmol/min/kPa)

-0.116

-0.652

0.339

-0.767

-0.832

-1.212

± SE

± 0.226

± 0.226

± 0.295

± 0.322

± 0.279

± 0.222

n =

68

63

48

46

20

17

p =

0.61

0.0047

0.25

0.02

0.0063

<0.0001

DLco(% pred.)

-2.124

-7.361

-0.697

-7.801

-8.288

-11.861

± SE

± 1.809

± 1.790

± 2.239

± 2.231

± 3.034

± 2.580

n =

68

63

48

46

20

17

p =

0.24

<0.0001

0.76

0.0008

0.011

<0.0001

CPI

0.509

5.471

-1.086

5.065

6.854

9.867

± SE

± 1.474

± 1.459

± 1.812

± 1.810

± 2.488

± 2.118

n =

68

64

47

46

21

18

p =

0.73

0.0003

0.55

0.0065

0.010

<0.0001

  1. † Least Square Means, relative SE and within groups p values were calculated from the model described in method