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Table 2 LOCF-method vs. Completers/non-Completers analyses of VC, DLco, and CPI: changes between last measurement and base line

From: Lung function in idiopathic pulmonary fibrosis - extended analyses of the IFIGENIA trial

  LOCF-method Completers Non-Completers
Change from baseline † NAC PLA NAC PLA NAC PLA
VC (l) -0.057 -0.233 -0.062 -0.148 -0.207 -0.424
± SE ± 0.054 ± 0.057 ± 0.063 ± 0.069 ± 0.114 ± 0.119
n = 71 68 55 51 16 17
p = 0.29 <0.0001 0.33 0.036 0.084 0.0017
VC (% pred.) -0.830 -5.634 -1.245 -3.178 -2.849 -10.109
± SE ± 1.426 ± 1.539 ± 1.655 ± 1.837 ± 3.241 ± 3.590
n = 71 68 55 51 16 17
p = 0.56 0.0004 0.434 0.087 0.39 0.0098
DLco (mmol/min/kPa) -0.116 -0.652 0.339 -0.767 -0.832 -1.212
± SE ± 0.226 ± 0.226 ± 0.295 ± 0.322 ± 0.279 ± 0.222
n = 68 63 48 46 20 17
p = 0.61 0.0047 0.25 0.02 0.0063 <0.0001
DLco(% pred.) -2.124 -7.361 -0.697 -7.801 -8.288 -11.861
± SE ± 1.809 ± 1.790 ± 2.239 ± 2.231 ± 3.034 ± 2.580
n = 68 63 48 46 20 17
p = 0.24 <0.0001 0.76 0.0008 0.011 <0.0001
CPI 0.509 5.471 -1.086 5.065 6.854 9.867
± SE ± 1.474 ± 1.459 ± 1.812 ± 1.810 ± 2.488 ± 2.118
n = 68 64 47 46 21 18
p = 0.73 0.0003 0.55 0.0065 0.010 <0.0001
  1. † Least Square Means, relative SE and within groups p values were calculated from the model described in method