From: Lung function in idiopathic pulmonary fibrosis - extended analyses of the IFIGENIA trial
LOCF-method | Completers | Non-Completers | ||||
---|---|---|---|---|---|---|
Change from baseline † | NAC | PLA | NAC | PLA | NAC | PLA |
VC (l) | -0.057 | -0.233 | -0.062 | -0.148 | -0.207 | -0.424 |
± SE | ± 0.054 | ± 0.057 | ± 0.063 | ± 0.069 | ± 0.114 | ± 0.119 |
n = | 71 | 68 | 55 | 51 | 16 | 17 |
p = | 0.29 | <0.0001 | 0.33 | 0.036 | 0.084 | 0.0017 |
VC (% pred.) | -0.830 | -5.634 | -1.245 | -3.178 | -2.849 | -10.109 |
± SE | ± 1.426 | ± 1.539 | ± 1.655 | ± 1.837 | ± 3.241 | ± 3.590 |
n = | 71 | 68 | 55 | 51 | 16 | 17 |
p = | 0.56 | 0.0004 | 0.434 | 0.087 | 0.39 | 0.0098 |
DLco (mmol/min/kPa) | -0.116 | -0.652 | 0.339 | -0.767 | -0.832 | -1.212 |
± SE | ± 0.226 | ± 0.226 | ± 0.295 | ± 0.322 | ± 0.279 | ± 0.222 |
n = | 68 | 63 | 48 | 46 | 20 | 17 |
p = | 0.61 | 0.0047 | 0.25 | 0.02 | 0.0063 | <0.0001 |
DLco(% pred.) | -2.124 | -7.361 | -0.697 | -7.801 | -8.288 | -11.861 |
± SE | ± 1.809 | ± 1.790 | ± 2.239 | ± 2.231 | ± 3.034 | ± 2.580 |
n = | 68 | 63 | 48 | 46 | 20 | 17 |
p = | 0.24 | <0.0001 | 0.76 | 0.0008 | 0.011 | <0.0001 |
CPI | 0.509 | 5.471 | -1.086 | 5.065 | 6.854 | 9.867 |
± SE | ± 1.474 | ± 1.459 | ± 1.812 | ± 1.810 | ± 2.488 | ± 2.118 |
n = | 68 | 64 | 47 | 46 | 21 | 18 |
p = | 0.73 | 0.0003 | 0.55 | 0.0065 | 0.010 | <0.0001 |