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  1. Content type: Review

    Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive disease characterized by the aberrant accumulation of fibrotic tissue in the lungs parenchyma, associated with significant morbidity and poor progn...

    Authors: Giacomo Sgalla, Bruno Iovene, Mariarosaria Calvello, Margherita Ori, Francesco Varone and Luca Richeldi

    Citation: Respiratory Research 2018 19:32

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  2. Content type: Research

    COPD is a complex, heterogeneous disease characterised by progressive development of airflow limitation. Spirometry provides little information about key aspects of pathology and is poorly related to clinical ...

    Authors: Kristoffer Ostridge, Nicholas P. Williams, Viktoriya Kim, Stephen Harden, Simon Bourne, Stuart C. Clarke, Emmanuel Aris, Sonia Mesia-Vela, Jeanne-Marie Devaster, Andrew Tuck, Anthony Williams, Stephen Wootton, Karl J. Staples and Tom M. A. Wilkinson

    Citation: Respiratory Research 2018 19:31

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  3. Content type: Research

    The literature is scarce regarding the prevalence and clinical impact of IgG subclass deficiency in COPD. We investigated the prevalence of IgG subclass deficiencies and their association with exacerbations an...

    Authors: Fernando Sergio Leitao Filho, Seung Won Ra, Andre Mattman, Robert S. Schellenberg, Gerard J. Criner, Prescott G. Woodruff, Stephen C. Lazarus, Richard Albert, John E. Connett, Meilan K. Han, Fernando J. Martinez, Janice M. Leung, S. F. Paul Man, Shawn D. Aaron, Robert M. Reed and Don D. Sin

    Citation: Respiratory Research 2018 19:30

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  4. Content type: Research

    ATP-regulated potassium channels (KATP) regulate pulmonary vascular tone and are involved in hypoxic pulmonary vasoconstriction (HPV). In patients with inflammation like sepsis or ARDS, HPV is impaired, result...

    Authors: Maurizio Turzo, Julian Vaith, Felix Lasitschka, Markus A. Weigand and Cornelius J. Busch

    Citation: Respiratory Research 2018 19:29

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  5. Content type: Research

    Recently, increased tumor incidence and cancer-related mortality have been reported among patients with obstructive sleep apnea (OSA). Intermittent hypoxia (IH), the hallmark feature of OSA, contributes to the...

    Authors: Lian Li, Fangyuan Ren, Chao Qi, Leiqian Xu, Yinshan Fang, Maoli Liang, Jing Feng, Baoyuan Chen, Wen Ning and Jie Cao

    Citation: Respiratory Research 2018 19:28

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  6. Content type: Research

    Endothelial cell (EC) regeneration is essential for inflammation resolution and vascular integrity recovery after inflammatory vascular injury. Cdc42 is a central regulator of cell survival and vessel formatio...

    Authors: Jiawen Lv, Junchao Zeng, Fukun Guo, Yiran Li, Mengying Xu, Yuanxiong Cheng, Lin Zhang, Shaoxi Cai, Yinghua Chen, Yi Zheng and Guodong Hu

    Citation: Respiratory Research 2018 19:27

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  7. Content type: Research

    A significant proportion of patients with chronic obstructive pulmonary disease (COPD) remain undiagnosed. Characterizing these patients can increase our understanding of the ‘hidden’ burden of COPD and the ef...

    Authors: Kate M. Johnson, Stirling Bryan, Shahzad Ghanbarian, Don D. Sin and Mohsen Sadatsafavi

    Citation: Respiratory Research 2018 19:26

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  8. Content type: Research

    Our aim was to investigate total and regional lung delivery of salbutamol in subjects with idiopathic pulmonary fibrosis (IPF).

    Authors: Omar S. Usmani, Martyn F. Biddiscombe, Shuying Yang, Sally Meah, Eunice Oballa, Juliet K. Simpson, William A. Fahy, Richard P. Marshall, Pauline T. Lukey and Toby M. Maher

    Citation: Respiratory Research 2018 19:25

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  9. Content type: Research

    Idiopathic pulmonary fibrosis (IPF) is the most rapidly progressive and fatal fibrotic disorder, with no curative therapies. The signal transducer and activator of transcription 3 (STAT3) protein is activated ...

    Authors: Javier Milara, Gracia Hernandez, Beatriz Ballester, Anselm Morell, Inés Roger, P. Montero, Juan Escrivá, José M. Lloris, Maria Molina-Molina, Esteban Morcillo and Julio Cortijo

    Citation: Respiratory Research 2018 19:24

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  10. Content type: Research

    Surfactant Protein-A (SP-A) is a major protein component of surfactant and plays a role in surfactant-related functions and innate immunity. Human SP-A consists of two functional genes, SFTPA1 and SFTPA2, enco...

    Authors: Nithyananda Thorenoor, Xuesheng Zhang, Todd M. Umstead, E. Scott Halstead, David S. Phelps and Joanna Floros

    Citation: Respiratory Research 2018 19:23

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  11. Content type: Research

    Planar cell polarity (PCP) coordinates the patterning and orientation of cells and their structures along tissue planes, and although its acquisition during the formation of airway epithelium has been describe...

    Authors: Takuya Tsuji, Ryosuke Nakamura, Tatsuya Katsuno, Yo Kishimoto, Atsushi Suehiro, Masaru Yamashita, Ryuji Uozumi, Tatsuo Nakamura, Ichiro Tateya and Koichi Omori

    Citation: Respiratory Research 2018 19:22

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  12. Content type: Research

    Thrombocytosis has been associated with COPD prevalence and increased all-cause mortality in patients with acute exacerbation of COPD (AECOPD); but whether it is associated with morbidity in stable COPD is unk...

    Authors: Ashraf Fawzy, Nirupama Putcha, Laura M. Paulin, Carrie P. Aaron, Wassim W. Labaki, MeiLan K. Han, Robert A. Wise, Richard E. Kanner, Russell P. Bowler, R. Graham Barr and Nadia N. Hansel

    Citation: Respiratory Research 2018 19:20

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  13. Content type: Research

    Abnormal apoptosis of lung endothelial cells has been observed in emphysematous lung tissue and has been suggested to be an important upstream event in the pathogenesis of chronic obstructive pulmonary disease...

    Authors: Ying-Jiao Long, Xiao-Peng Liu, Shan-Shan Chen, Dan-Dan Zong, Yan Chen and Ping Chen

    Citation: Respiratory Research 2018 19:21

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  14. Content type: Research

    Single-inhaler fluticasone furoate/umeclidinium/vilanterol (FF/UMEC/VI) 100/62.5/25 μg has been shown to improve lung function and health status, and reduce exacerbations, versus budesonide/formoterol in patie...

    Authors: Peter R. Bremner, Ruby Birk, Noushin Brealey, Afisi S. Ismaila, Chang-Qing Zhu and David A. Lipson

    Citation: Respiratory Research 2018 19:19

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  15. Content type: Review

    Imaging holds an important role in the diagnosis of lung diseases. Along with clinical tests, noninvasive imaging techniques provide complementary and valuable information that enables a complete differential ...

    Authors: Julien Dimastromatteo, Eric J. Charles and Victor E. Laubach

    Citation: Respiratory Research 2018 19:17

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  16. Content type: Research

    Viral-induced asthma exacerbations, which exhibit both Th1-type neutrophilia and Th2-type inflammation, associate with secretion of Interleukin (IL)-1β. IL-1β induces neutrophilic inflammation. It may also inc...

    Authors: Irma Mahmutovic Persson, Mandy Menzel, Sangeetha Ramu, Samuel Cerps, Hamid Akbarshahi and Lena Uller

    Citation: Respiratory Research 2018 19:16

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  17. Content type: Research

    We carried out a systematic review and meta-analysis with the aim to evaluate the efficacy of long-acting bronchodilators on exercise capacity in COPD patients.

    Authors: Fabiano Di Marco, Giovanni Sotgiu, Pierachille Santus, Denis E. O’Donnell, Kai-Michael Beeh, Simone Dore, Maria Adelaide Roggi, Lisa Giuliani, Francesco Blasi and Stefano Centanni

    Citation: Respiratory Research 2018 19:18

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  18. Content type: Research

    Accumulation mode particles (AMP) are formed from engine combustion and make up the inhalable vapour cloud of ambient particulate matter pollution. Their small size facilitates dispersal and subsequent exposur...

    Authors: Angela M. Fonceca, Graeme R. Zosky, Elizabeth M. Bozanich, Erika N. Sutanto, Anthony Kicic, Paul S. McNamara, Darryl A. Knight, Peter D. Sly, Debra J. Turner and Stephen M. Stick

    Citation: Respiratory Research 2018 19:15

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  19. Content type: Research

    Fibrosis is a delayed side effect of radiation therapy (RT). Connective tissue growth factor (CTGF) promotes the development of fibrosis in multiple settings, including pulmonary radiation injury.

    Authors: Mark D. Sternlicht, Ute Wirkner, Sebastian Bickelhaupt, Ramon Lopez Perez, Alexandra Tietz, Kenneth E. Lipson, Todd W. Seeley and Peter E. Huber

    Citation: Respiratory Research 2018 19:14

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  20. Content type: Research

    Exposure to noxious gases and particles contained in both tobacco smoking (TS) and biomass smoke (BS) are well recognized environmental risk factors for chronic obstructive pulmonary disease (COPD). COPD is ch...

    Authors: Jordi Olloquequi, Sergio Jaime, Viviana Parra, Elizabeth Cornejo-Córdova, Gonzalo Valdivia, Àlvar Agustí and Rafael Silva O.

    Citation: Respiratory Research 2018 19:13

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  21. Content type: Review

    Clinical practice guidelines are ubiquitous and are developed to provide recommendations for the management of many diseases, including chronic obstructive pulmonary disease. The development of these guideline...

    Authors: Marc Miravitlles, Nicolas Roche, João Cardoso, David Halpin, Zaurbek Aisanov, Hannu Kankaanranta, Vladimir Kobližek, Paweł Śliwiński, Leif Bjermer, Michael Tamm, Francesco Blasi and Claus F. Vogelmeier

    Citation: Respiratory Research 2018 19:11

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  22. Content type: Research

    Severe and uncontrolled asthma is associated with increased risk of exacerbations and death. A substantial proportion of asthma patients have poor asthma control, and a concurrent COPD diagnosis often increase...

    Authors: Kjell Larsson, Björn Ställberg, Karin Lisspers, Gunilla Telg, Gunnar Johansson, Marcus Thuresson and Christer Janson

    Citation: Respiratory Research 2018 19:12

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  23. Content type: Review

    Inhaled drug delivery is the cornerstone treatment for asthma and chronic obstructive pulmonary disease (COPD). However, use of inhaler devices can be challenging, potentially leading to critical errors in han...

    Authors: Omar Sharif Usmani, Federico Lavorini, Jonathan Marshall, William Christopher Nigel Dunlop, Louise Heron, Emily Farrington and Richard Dekhuijzen

    Citation: Respiratory Research 2018 19:10

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  24. Content type: Letter to the Editor

    Dysregulation of VEGF-A bioavailability has been implicated in the development of lung injury/fibrosis, exemplified by Idiopathic Pulmonary Fibrosis (IPF). VEGF-A is a target of the hypoxic response via its tr...

    Authors: Shaney L. Barratt, Thomas Blythe, Khadija Ourradi, Caroline Jarrett, Gavin I. Welsh, David O. Bates and Ann B. Millar

    Citation: Respiratory Research 2018 19:9

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  25. Content type: Commentary

    While the N-terminal pro-brain-type natriuretic peptide (NT-proBNP) at rest is known to be associated with prognosis in pulmonary arterial hypertension (PAH), it is unclear if the NT-proBNP response to exercis...

    Authors: J. Kutsch, C. Faul, W. von Scheidt, M. Schwaiblmair and T. M. Berghaus

    Citation: Respiratory Research 2018 19:8

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