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  1. Content type: Research

    Adhesion G-protein coupled receptor F5 (ADGRF5) was recently identified as an essential regulator of pulmonary surfactant homeostasis in alveolar type II cells. We previously showed that in addition to abnorma...

    Authors: Fumimasa Kubo, Donna Maretta Ariestanti, Souta Oki, Taku Fukuzawa, Ryotaro Demizu, Tomoya Sato, Rahmaningsih Mara Sabirin, Shigehisa Hirose and Nobuhiro Nakamura

    Citation: Respiratory Research 2019 20:11

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  2. Content type: Research

    Idiopathic pulmonary fibrosis (IPF) is characterized by a progressive and irreversible respiratory failure. Non-invasive markers of disease activity are essential for prognosis and evaluation of early response...

    Authors: Benjamin Bondue, Amélie Castiaux, Gaetan Van Simaeys, Céline Mathey, Félicie Sherer, Dominique Egrise, Simon Lacroix, François Huaux, Gilles Doumont and Serge Goldman

    Citation: Respiratory Research 2019 20:10

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  3. Content type: Review

    Originally, studies on exhaled droplets explored properties of airborne transmission of infectious diseases. More recently, the interest focuses on properties of exhaled droplets as biomarkers, enabled by the ...

    Authors: B. Bake, P. Larsson, G. Ljungkvist, E. Ljungström and A-C Olin

    Citation: Respiratory Research 2019 20:8

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  4. Content type: Research

    We have shown that phospholipase Cε (PLCε), an effector of Ras and Rap1 small GTPases, plays pivotal roles in inflammation and inflammation-associated carcinogenesis by augmenting proinflammatory cytokine prod...

    Authors: Kanoko Umezawa, Tatsuya Nagano, Kazuyuki Kobayashi, Ryota Dokuni, Masahiro Katsurada, Masatsugu Yamamoto, Yoko Yoshikawa, Tohru Kataoka and Yoshihiro Nishimura

    Citation: Respiratory Research 2019 20:9

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  5. Content type: Review

    Exhaled biomarkers may be related to disease processes in idiopathic pulmonary fibrosis (IPF) however their clinical role remains unclear. We performed a systematic review to investigate whether breath biomark...

    Authors: Conal Hayton, Dayle Terrington, Andrew M. Wilson, Nazia Chaudhuri, Colm Leonard and Stephen J. Fowler

    Citation: Respiratory Research 2019 20:7

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  6. Content type: Research

    The burden of chronic obstructive lung disease (COPD) is increasing in women, with recent evidence suggesting gender differences in disease characteristics and potentially in treatment outcomes.

    Authors: Jadwiga A. Wedzicha, Dave Singh, Ioanna Tsiligianni, Christine Jenkins, Sebastian Fucile, Robert Fogel, Steven Shen, Pankaj Goyal, Karen Mezzi and Konstantinos Kostikas

    Citation: Respiratory Research 2019 20:4

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  7. Content type: Research

    Previous studies have identified lung, sputum or blood transcriptomic biomarkers associated with the severity of airflow limitation in COPD. Yet, it is not clear whether the lung pathobiology is mirrored by th...

    Authors: Rosa Faner, Jarrett D. Morrow, Sandra Casas-Recasens, Suzanne M. Cloonan, Guillaume Noell, Alejandra López-Giraldo, Ruth Tal-Singer, Bruce E. Miller, Edwin K. Silverman, Alvar Agustí and Craig P. Hersh

    Citation: Respiratory Research 2019 20:5

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  8. Content type: Research

    Little is known on the pulmonary gradients of oxyhemoglobin, carboxyhemoglobin and methemoglobin in pulmonary arterial hypertension (PAH). We sought to determine these gradients in group 1 PAH and assess their...

    Authors: Ghaleb Khirfan, Mostafa K. Ahmed, Michael D. Faulx, Wael Dakkak, Raed A. Dweik and Adriano R. Tonelli

    Citation: Respiratory Research 2019 20:6

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  9. Content type: Review

    Circular RNAs (CircRNAs), as a new class of non-coding RNA molecules that, unlike linear RNAs, have covalently closed loop structures from the ligation of exons, introns, or both. CircRNAs are widely expressed...

    Authors: Jian Wang, Mengchan Zhu, Jue Pan, Cuicui Chen, Shijin Xia and Yuanlin Song

    Citation: Respiratory Research 2019 20:3

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  10. Content type: Research

    Galectin-3 is a 32 kDa protein secreted by macrophages involved in processes such as cell activation, chemotaxis and phagocytosis. Galectin-3 has previously been shown to improve the ability of airway macropha...

    Authors: Melanie Erriah, Kavita Pabreja, Michael Fricker, Katherine J. Baines, Louise E. Donnelly, Johan Bylund, Anna Karlsson and Jodie L. Simpson

    Citation: Respiratory Research 2019 20:1

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  11. Content type: Research

    Retinoid X receptors (RXRs) are members of the nuclear receptor (NR) superfamily that mediate signalling by 9-cis retinoic acid, a vitamin A derivative. RXRs play key roles not only as homodimers but also as h...

    Authors: Daisuke Morichika, Nobuaki Miyahara, Utako Fujii, Akihiko Taniguchi, Naohiro Oda, Satoru Senoo, Mikio Kataoka, Mitsune Tanimoto, Hiroki Kakuta, Katsuyuki Kiura, Yoshinobu Maeda and Arihiko Kanehiro

    Citation: Respiratory Research 2019 20:2

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  12. Content type: Research

    This study investigated the function of SMAD3 (SMAD family member 3) in regulating PAX6 (paired box 6) in non-small cell lung cancer.

    Authors: Zhe Qian, Qiankun Zhang, Ying Hu, Tongmei Zhang, Jie Li, Zan Liu, Hua Zheng, Yuan Gao, Wenyun Jia, Aimin Hu, Baolan Li and Jiqing Hao

    Citation: Respiratory Research 2018 19:262

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  13. Content type: Research

    Chronic obstructive pulmonary disease (COPD) patients may experience an acute exacerbation (AECOPD) that requires hospitalisation. The length of hospital stay (LHS) has a great economic impact on the health-ca...

    Authors: Ernesto Crisafulli, Antonella Ielpo, Enric Barbeta, Adrian Ceccato, Arturo Huerta, Albert Gabarrús, Néstor Soler, Alfredo Chetta and Antoni Torres

    Citation: Respiratory Research 2018 19:261

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  14. Content type: Research

    Growing evidences suggested that the Mycobacterium tuberculosis complex (MTBC) lineages can determine the clinical outcome of pulmonary and extra-pulmonary tuberculosis. However, limited data only available revea...

    Authors: Bright Varghese, Mushira Enani, Abdulrahman Alrajhi, Sameera Al Johani, Ali Albarak, Sahar Althawadi, Noura Elkhizzi, Hawra AlGhafli, Mohammed Shoukri and Sahal Al - Hajoj

    Citation: Respiratory Research 2018 19:259

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  15. Content type: Research

    Riociguat is a soluble guanylate cyclase stimulator approved for pulmonary arterial hypertension (PAH) and chronic thromboembolic pulmonary hypertension (CTPEH). The objective of this study was to evaluate rig...

    Authors: Alberto M. Marra, Michael Halank, Nicola Benjamin, Eduardo Bossone, Antonio Cittadini, Christina A. Eichstaedt, Benjamin Egenlauf, Satenik Harutyunova, Christine Fischer, Henning Gall, Hossein Ardeschir Ghofrani, Marius M. Hoeper, Tobias J. Lange, Karen M. Olsson, Hans Klose and Ekkehard Grünig

    Citation: Respiratory Research 2018 19:258

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  16. Content type: Research

    Chronic obstructive pulmonary disease (COPD) is associated with a two-to-five fold increase in the risk of coronary artery disease independent of shared risk factors. This association is hypothesized to be med...

    Authors: Surya P. Bhatt, Hrudaya P. Nath, Young-il Kim, Rekha Ramachandran, Jubal R. Watts, Nina L. J. Terry, Sushil Sonavane, Swati P. Deshmane, Prescott G. Woodruff, Elizabeth C. Oelsner, Sandeep Bodduluri, MeiLan K. Han, Wassim W. Labaki, J. Michael Wells, Fernando J. Martinez, R. Graham Barr…

    Citation: Respiratory Research 2018 19:257

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  17. Content type: Letter to the Editor

    We performed a post-hoc analysis of the OLiVIA-study investigating whether current and ex-smoking asthmatics with small airways dysfunction (SAD) show a better response in airway hyperresponsiveness (AHR) to s...

    Authors: Fajri Gafar, Ilse M. Boudewijn, Claire A. Cox, Judith M. Vonk, Siebrig Schokker, Anne J. Lexmond, Henderik W. Frijlink, Paul Hagedoorn, Dirkje S. Postma and Maarten van den Berge

    Citation: Respiratory Research 2018 19:256

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  18. Content type: Letter to the Editor

    Pulmonary aspiration of gastric refluxate (PAGR) has been demonstrated in association with pulmonary inflammation in school aged children with Cystic Fibrosis (CF). We sought to determine if similar findings w...

    Authors: D. Clarke, I. Gorman, F. Ringholz, M. McDermott, DW. Cox, P. Greally, B. Linnane and P. Mc Nally

    Citation: RESPIRATORY RESEARCH 2018 19:255

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  19. Content type: Research

    Recent studies break with traditional opinion that the lower respiratory tract is sterile, and increasingly focus on the lung microbiome and disease. Smoking, as an important etiology of inflammatory lung dise...

    Authors: Rui Zhang, Ling Chen, Lei Cao, Kang-jie Li, Yao Huang, Xiao-qian Luan and Ge Li

    Citation: RESPIRATORY RESEARCH 2018 19:253

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  20. Content type: Research

    Pulmonary arterial hypertension (PAH) is related to inflammation, and the lncRNA H19 is associated with inflammation. However, whether PDGF-BB-H19-let-7b-AT1R axis contributes to the pathogenesis of PAH has not b...

    Authors: Hua Su, Xiaoling Xu, Chao Yan, Yangfeng Shi, Yanjie Hu, Liangliang Dong, Songmin Ying, Kejing Ying and Ruifeng Zhang

    Citation: RESPIRATORY RESEARCH 2018 19:254

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  21. Content type: Research

    Reduced lung function predicts increased mortality, but its prevalence may vary depending on definition considered, use of bronchodilation and applied reference values. We aimed to assess lung function abnorma...

    Authors: Alexandra Lenoir, Jean-William Fitting, Pedro-Manuel Marques-Vidal, Peter Vollenweider and Laurent P. Nicod

    Citation: RESPIRATORY RESEARCH 2018 19:250

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  22. Content type: Research

    Exacerbations of chronic obstructive pulmonary disease (COPD) are associated with loss of lung function and poor outcomes for patients. However, there are limited data on the time course of changes in forced e...

    Authors: Henrik Watz, Kay Tetzlaff, Helgo Magnussen, Achim Mueller, Roberto Rodriguez-Roisin, Emiel F. M. Wouters, Claus Vogelmeier and Peter M. A. Calverley

    Citation: RESPIRATORY RESEARCH 2018 19:251

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  23. Content type: Research

    Candidate gene and genome-wide association studies have identified hundreds of asthma risk loci. The majority of associated variants, however, are not known to have any biological function and are believed to ...

    Authors: Matthew D. C. Neville, Jihoon Choi, Jonathan Lieberman and Qing Ling Duan

    Citation: RESPIRATORY RESEARCH 2018 19:248

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  24. Content type: Research

    The Global Initiative for Chronic Obstructive Lung Disease (GOLD) severity stage classifies Chronic Obstructive Pulmonary Disease (COPD) into groups based on symptoms, exacerbations and forced expiratory volum...

    Authors: Robert W. V. Flynn, Thomas M. MacDonald, James D. Chalmers and Stuart Schembri

    Citation: RESPIRATORY RESEARCH 2018 19:249

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  25. Content type: Research

    Few studies have investigated the associations between outdoor air pollution and outpatient visits for respiratory diseases (RDs) in general population.

    Authors: Shanshan Wang, Yifan Li, Aimin Niu, Yao Liu, Lili Su, Wanmei Song, Jinyue Liu, Yunxia Liu and Huaichen Li

    Citation: RESPIRATORY RESEARCH 2018 19:246

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  26. Content type: Research

    Host-associated microbial communities have important roles in tissue homeostasis and overall health. Severe perturbations can occur within these microbial communities during critical illness due to underlying ...

    Authors: Daphnée Lamarche, Jennie Johnstone, Nicole Zytaruk, France Clarke, Lori Hand, Dessi Loukov, Jake C. Szamosi, Laura Rossi, Louis P. Schenck, Chris P. Verschoor, Ellen McDonald, Maureen O. Meade, John C. Marshall, Dawn M. E. Bowdish, Tim Karachi, Diane Heels-Ansdell…

    Citation: RESPIRATORY RESEARCH 2018 19:245

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  27. Content type: Research

    Cytotoxic lymphocytes are increased in the airways of COPD patients. Whether this increase is driven primarily by the disease or by smoking is not clear, nor whether it correlates with the rate of decline in l...

    Authors: Jonas Eriksson Ström, Jamshid Pourazar, Robert Linder, Anders Blomberg, Anne Lindberg, Anders Bucht and Annelie F. Behndig

    Citation: RESPIRATORY RESEARCH 2018 19:244

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  28. Content type: Research

    Acute lung injury (ALI) is a life-threatening lung disease where alveolar macrophages (AMs) play a central role both in the early phase to initiate inflammatory responses and in the late phase to promote tissu...

    Authors: Huaizheng Liu, Kefu Zhou, Liangkan Liao, Tianyi Zhang, Mingshi Yang and Chuanzheng Sun

    Citation: RESPIRATORY RESEARCH 2018 19:243

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  29. Content type: Research

    Cirrhosis always goes with profound immunity compromise, and makes those patients easily be the target of pneumonia. Cirrhotic patients with pneumonia have a dramatically increased mortality. To recognize the ...

    Authors: Lichen Xu, Shuangwei Ying, Jianhua Hu, Yunyun Wang, Meifang Yang, Tiantian Ge, Chunhong Huang, Qiaomai Xu, Haihong Zhu, Zhi Chen and Weihang Ma

    Citation: RESPIRATORY RESEARCH 2018 19:242

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  30. Content type: Research

    The main causes of COPD are tobacco smoking (COPD-TS) and biomass smoke exposure (COPD-BS). COPD-TS is known to induce changes in adipokines, incretins, and peptide hormones, frequent biomarkers of inflammatio...

    Authors: Oliver Pérez-Bautista, Martha Montaño, Rogelio Pérez-Padilla, Joaquín Zúñiga-Ramos, Mariana Camacho-Priego, Tonatiuh Barrientos-Gutiérrez, Ivette Buendía-Roldan, Yadira Velasco-Torres and Carlos Ramos

    Citation: RESPIRATORY RESEARCH 2018 19:239

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  31. Content type: Research

    Different histological subtypes of non-small cell lung cancer (NSCLC) show different molecular characteristics and responses to therapeutic strategy. Identification of specific gene, clarification of its speci...

    Authors: Fei Han, Ming-qian Zhang, Wen-bin Liu, Lei Sun, Xiang-lin Hao, Li Yin, Xiao Jiang, Jia Cao and Jin-yi Liu

    Citation: RESPIRATORY RESEARCH 2018 19:241

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  32. Content type: Research

    Ex vivo lung perfusion (EVLP) is used by an increasing number of transplant centres. It is still controversial whether an acellular or cellular (erythrocyte enriched) perfusate is preferable. The aim of this p...

    Authors: Jasmin Steinmeyer, Simon Becker, Murat Avsar, Jawad Salman, Klaus Höffler, Axel Haverich, Gregor Warnecke, Christian Mühlfeld, Matthias Ochs and Anke Schnapper-Isl

    Citation: RESPIRATORY RESEARCH 2018 19:238

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  33. Content type: Research

    Adrenal hormone metabolite levels are altered in acute illnesses such as community-acquired pneumonia (CAP). Our aim was to investigate associations of sex and mineralocorticoid hormone metabolites with short-...

    Authors: Seline Zurfluh, Manuela Nickler, Manuel Ottiger, Christian Steuer, Alexander Kutz, Mirjam Christ-Crain, Werner Zimmerli, Robert Thomann, Claus Hoess, Christoph Henzen, Luca Bernasconi, Andreas Huber, Beat Mueller and Philipp Schuetz

    Citation: RESPIRATORY RESEARCH 2018 19:240

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  34. Content type: Research

    Sarcoidosis is a systemic inflammatory multi-organ disease almost always affecting the lungs. The etiology remains unknown, but the hallmark of sarcoidosis is formation of non-caseating epithelioid cells granu...

    Authors: Marcus O. D. Sjödin, Antonio Checa, Mingxing Yang, Sven-Erik Dahlén, Åsa M. Wheelock, Anders Eklund, Johan Grunewald and Craig E. Wheelock

    Citation: RESPIRATORY RESEARCH 2018 19:236

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  35. Content type: Research

    The burden of asthma and COPD among patients is high and people affected are frequently hospitalized due to exacerbations. There are numerous reasons for the lack of disease control in asthma and COPD patients...

    Authors: Claudia Gregoriano, Thomas Dieterle, Anna-Lisa Breitenstein, Selina Dürr, Amanda Baum, Sabrina Maier, Isabelle Arnet, Kurt E. Hersberger and Jörg D. Leuppi

    Citation: RESPIRATORY RESEARCH 2018 19:237

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  36. Content type: Research

    Either chronic or acute exposure to dust particles may lead to pneumoconiosis and lung cancer, and lung cancer mortality among patients diagnosed with pneumoconiosis is increasing. Utilizing genome-wide sequen...

    Authors: Lin Zhang, Changfu Hao, Ruonan Zhai, Di Wang, Jianhui Zhang, Lei Bao, Yiping Li and Wu Yao

    Citation: Respiratory Research 2018 19:235

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  37. Content type: Research

    Individuals with respiratory disease are being increasingly exposed to wildfire smoke as populations encroach further into forested regions and climate change continues to bring higher temperatures with lower ...

    Authors: Eugene Roscioli, Rhys Hamon, Susan E. Lester, Hubertus P. A. Jersmann, Paul N. Reynolds and Sandra Hodge

    Citation: Respiratory Research 2018 19:234

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  38. Content type: Research

    Idiopathic pulmonary fibrosis (IPF) is characterized by progressive scarring of the lung parenchyma, leading to respiratory failure and death. High resolution computed tomography of the chest is often diagnost...

    Authors: Marc A. Sala, Yalbi Itzel Balderas-Martínez, Ivette Buendía-Roldan, Hiam Abdala-Valencia, Kiwon Nam, Manu Jain, Sangeeta Bhorade, Ankit Bharat, Paul A. Reyfman, Karen M. Ridge, Annie Pardo, Jacob I. Sznajder, G. R. Scott Budinger, Alexander V. Misharin and Moises Selman

    Citation: Respiratory Research 2018 19:233

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  39. Content type: Research

    Mitochondrial damage leading to oxidant stress may play an important role in the pathogenesis of airflow obstruction and emphysema. NLPR3 inflammasome can be activated by mitochondrial ROS (mtROS) and other st...

    Authors: Feng Li, Mengmeng Xu, Muyun Wang, Lei Wang, Hanying Wang, Hai Zhang, Yuqing Chen, Jicheng Gong, Junfeng(Jim) Zhang, Ian M. Adcock, Kian Fan Chung and Xin Zhou

    Citation: Respiratory Research 2018 19:230

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  40. Content type: Research

    Sepsis is a multi-system syndrome that remains the leading cause of mortality and critical illness worldwide, with hemodynamic support being one of the cornerstones of the acute management of sepsis. We used a...

    Authors: Margaret R. Passmore, Liam Byrne, Nchafatso G. Obonyo, Louise E. See Hoe, Ai-Ching Boon, Sara D. Diab, Kimble R. Dunster, Kavita Bisht, John-Paul Tung, Mohd H. Fauzi, Monica Narula, Sanne E. Pedersen, Arlanna Esguerra-Lallen, Gabriela Simonova, Annette Sultana, Chris M. Anstey…

    Citation: Respiratory Research 2018 19:231

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  41. Content type: Research

    Few longitudinal studies examine inflammation and lung function in asthma. We sought to determine the cytokines that reduce airflow, and the influence of respiratory viral infections on these relationships.

    Authors: Toby C. Lewis, Ediri E. Metitiri, Graciela B. Mentz, Xiaodan Ren, Ashley R. Carpenter, Adam M. Goldsmith, Kyra E. Wicklund, Breanna N. Eder, Adam T. Comstock, Jeannette M. Ricci, Sean R. Brennan, Ginger L. Washington, Kendall B. Owens, Bhramar Mukherjee, Thomas G. Robins, Stuart A. Batterman…

    Citation: Respiratory Research 2018 19:228

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  42. Content type: Research

    Endobronchial administration of lidocaine is commonly used for cough suppression during diagnostic bronchoscopy. Recently, nebulization of lidocaine during bronchoscopies under deep sedation with fiberoptic in...

    Authors: Tobias Müller, Christian Cornelissen and Michael Dreher

    Citation: Respiratory Research 2018 19:227

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  43. Content type: Research

    Hyperoxia is a frequently employed therapy for prematurely born infants, induces lung injury and contributes to development of bronchopulmonary dysplasia (BPD). BPD is characterized by decreased cellular proli...

    Authors: Mehboob Ali, Kathryn Heyob, Trent E. Tipple, Gloria S. Pryhuber and Lynette K. Rogers

    Citation: Respiratory Research 2018 19:229

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  44. Content type: Research

    A head-to-head study demonstrated the superiority of once-daily umeclidinium bromide/vilanterol (UMEC/VI) 62.5/25 mcg on trough forced expiratory volume in 1 s (FEV1) versus once-daily tiotropium/olodaterol (TIO/...

    Authors: M. T. Driessen, J. Whalen, B. Seewoodharry Buguth, L. A. Vallejo-Aparicio, I. P. Naya, Y. Asukai, B. Alcázar-Navarrete, M. Miravitlles, F. García-Río and N. A. Risebrough

    Citation: Respiratory Research 2018 19:224

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  45. Content type: Research

    Chronic obstructive pulmonary disease (COPD) is characterized by varying trajectories of decline. Information regarding the prognostic value of preventing short-term clinically important deterioration (CID) in...

    Authors: Ian P. Naya, Lee Tombs, Hana Muellerova, Christopher Compton and Paul W. Jones

    Citation: Respiratory Research 2018 19:222

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