%PDF-1.3
%
1 0 obj
<< /Rect
[ 409.080000 49.200000 419.880000 60.480000
] /Dest (G1037530) /Subtype /Link /Border
[ 0 0 0
] /Type /Annot
>>
endobj
2 0 obj
<< /Rect
[ 313.080000 424.620000 435.180000 433.140000
] /Subtype /Link /A
<< /S /URI /URI (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=8844055)
>> /Border
[ 0 0 0
] /Type /Annot
>>
endobj
3 0 obj
<< /D
[ 448 0 R /XYZ 366 586 null
]
>>
endobj
4 0 obj
<< /D
[ 391 0 R /XYZ 441 644 null
]
>>
endobj
5 0 obj
<< /Subtype /Type1 /FontDescriptor 1155 0 R /BaseFont /IJOONM+GillSans-Bold /Encoding /WinAnsiEncoding /Widths
[ 278 0 0 0 0 719 0 240 385 385 469 0 271 333 271 281 552 552 552 552 552 552 552 552 552 552 271 271 0 0 0 375 0 781 698 771 802 635 604 813 833 333 333 719 615 885 844 875 656 875 677 604 719 823 719 1167 0 708 0 438 0 438 0 0 0 531 583 500 583 552 302 542 583 271 271 552 271 958 583 594 583 583 448 427 406 583 510 781 552 510 521 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 500 0 0 0 0 0 0 0 0 0 278 0 0 0 0 0 0 0 0 0 0 0 0 333 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 584
] /FirstChar 32 /Type /Font /LastChar 215
>>
endobj
6 0 obj
<< /Subtype /XML /Type /Metadata /Length 3365
>>
stream
endstream
endobj
7 0 obj
<< /Rect
[ 450.780000 297.120000 554.040000 306.900000
] /Subtype /Link /A
<< /S /URI /URI (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=12801314)
>> /Border
[ 0 0 0
] /Type /Annot
>>
endobj
8 0 obj
<< /D
[ 1312 0 R /XYZ 497 489 null
]
>>
endobj
9 0 obj
<< /D
[ 1475 0 R /XYZ 421 268 null
]
>>
endobj
10 0 obj
<< /Type /ExtGState /SA false /OPM 1 /SM 0.020000
>>
endobj
11 0 obj
<< /W
[ 68
[ 630
] 80
[ 576
]
] /Subtype /CIDFontType2 /FontDescriptor 1595 0 R /BaseFont /IJPFDE+Symbol /CIDSystemInfo
<< /Registry (Adobe) /Ordering (Identity) /Supplement 0
>> /DW 1000 /Type /Font
>>
endobj
12 0 obj
<< /Rect
[ 55.140000 220.620000 95.340000 229.860000
] /Subtype /Link /A
<< /S /URI /URI (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=15824475)
>> /Border
[ 0 0 0
] /Type /Annot
>>
endobj
13 0 obj
<< /D
[ 1734 0 R /XYZ 412 254 null
]
>>
endobj
14 0 obj
<< /D
[ 350 0 R /XYZ 481 233 null
]
>>
endobj
15 0 obj
<< /Dests 342 0 R
>>
endobj
16 0 obj
<< /Rect
[ 218.280000 260.700000 229.140000 271.980000
] /Dest (G1050507) /Subtype /Link /Border
[ 0 0 0
] /Type /Annot
>>
endobj
17 0 obj
<< /Rect
[ 372.240000 654.180000 490.500000 663.900000
] /Subtype /Link /A
<< /S /URI /URI (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=9215937)
>> /Border
[ 0 0 0
] /Type /Annot
>>
endobj
18 0 obj
<< /Rect
[ 404.880000 93.120000 554.040000 102.900000
] /Subtype /Link /A
<< /S /URI /URI (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=6354022)
>> /Border
[ 0 0 0
] /Type /Annot
>>
endobj
19 0 obj
<< /D
[ 1320 0 R /XYZ 398 69 null
]
>>
endobj
20 0 obj
<< /D
[ 1312 0 R /XYZ 55 152 null
]
>>
endobj
21 0 obj
<< /Rect
[ 188.880000 342.960000 205.080000 354.240000
] /Dest (G1074391) /Subtype /Link /Border
[ 0 0 0
] /Type /Annot
>>
endobj
22 0 obj
<< /Rect
[ 55.140000 595.380000 296.100000 611.640000
] /Subtype /Link /A
<< /S /URI /URI (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=2461405)
>> /Border
[ 0 0 0
] /Type /Annot
>>
endobj
23 0 obj
<< /D
[ 1734 0 R /XYZ 205 526 null
]
>>
endobj
24 0 obj
<< /D
[ 89 0 R /XYZ 169 715 null
]
>>
endobj
25 0 obj
<< /D
[ 919 0 R /XYZ 313 97 null
]
>>
endobj
26 0 obj
<< /Rect
[ 506.520000 154.980000 517.380000 166.200000
] /Dest (G1046392) /Subtype /Link /Border
[ 0 0 0
] /Type /Annot
>>
endobj
27 0 obj
<< /Rect
[ 217.260000 373.620000 296.100000 383.400000
] /Subtype /Link /A
<< /S /URI /URI (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=14657867)
>> /Border
[ 0 0 0
] /Type /Annot
>>
endobj
28 0 obj
<< /Rect
[ 342.180000 501.120000 554.040000 510.900000
] /Subtype /Link /A
<< /S /URI /URI (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=16983053)
>> /Border
[ 0 0 0
] /Type /Annot
>>
endobj
29 0 obj
<< /D
[ 448 0 R /XYZ 82 509 null
]
>>
endobj
30 0 obj
<< /D
[ 919 0 R /XYZ 223 268 null
]
>>
endobj
31 0 obj
<< /Prev 211 0 R /Dest (G1024865) /Title (Management) /Next 1611 0 R /Parent 438 0 R
>>
endobj
32 0 obj
<< /Rect
[ 531.840000 225.480000 548.100000 236.700000
] /Dest (G1069075) /Subtype /Link /Border
[ 0 0 0
] /Type /Annot
>>
endobj
33 0 obj
<< /Rect
[ 382.380000 365.160000 554.040000 374.880000
] /Subtype /Link /A
<< /S /URI /URI (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=1527319)
>> /Border
[ 0 0 0
] /Type /Annot
>>
endobj
34 0 obj
<< /D
[ 539 0 R /XYZ 55 187 null
]
>>
endobj
35 0 obj
<< /D
[ 539 0 R /XYZ 146 80 null
]
>>
endobj
36 0 obj
<< /D
[ 183 0 R /XYZ 55 109 null
]
>>
endobj
37 0 obj
<< /Rect
[ 216.660000 60.960000 222.120000 72.240000
] /Dest (G1034186) /Subtype /Link /Border
[ 0 0 0
] /Type /Annot
>>
endobj
38 0 obj
<< /Filter /FlateDecode /Subtype /Type1C /Length 931
>>
stream
H|}LuZx;b؛wl&,S6-̭ e ceV^mG_`@(H)ˠӍّh&jb1MD2e>~$Zg|>O~0ǙBvQР-"j1l%T)m
]RQc9ul<%&Vpxol.>7???djM|6\| 8S6sxʗmݻ2lHEZ0ySo4:^0'&]v8LfkM9SaØ+ĎaiIzLɱ;^#루?_3UP ~R^4sg1i@48{$p{4=jc9ko@HHԃ/Dt(J>6fIwm/RJ.;!qYOY9?G4΄4#vI=\\Olΐ'umiqruj`w&
TwƎ+ ?/Q^DTi11]/]m$Gzs ڋjђsN;'5]g7{pp%jFmg|qƦ9mBGT)@սWcÚxjwheށxt~/}A/GПD6PSyuڼ 'ndK=3DVVgs;6Xwaը$_wI~#
jm:Q} DzN?z1wE*=]H{}<ǗXa%*
!]b59$$˛59GE8\;˫c,ldG##w#$7}Dƣ'̪ 0
endstream
endobj
39 0 obj
<< /Rect
[ 80.700000 220.620000 296.100000 230.400000
] /Subtype /Link /A
<< /S /URI /URI (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=12397422)
>> /Border
[ 0 0 0
] /Type /Annot
>>
endobj
40 0 obj
<< /D
[ 377 0 R /XYZ 275 144 null
]
>>
endobj
41 0 obj
<< /D
[ 490 0 R /XYZ 148 315 null
]
>>
endobj
42 0 obj
<< /First 221 0 R /Prev 231 0 R /Dest (G1017352) /Title (Key messages) /Next 1619 0 R /Last 380 0 R /Parent 53 0 R /Count -8
>>
endobj
43 0 obj
<< /Rect
[ 481.800000 60.960000 498.060000 72.240000
] /Dest (G1062463) /Subtype /Link /Border
[ 0 0 0
] /Type /Annot
>>
endobj
44 0 obj
<< /Rect
[ 55.140000 118.620000 135.420000 127.140000
] /Subtype /Link /A
<< /S /URI /URI (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=9604976)
>> /Border
[ 0 0 0
] /Type /Annot
>>
endobj
45 0 obj
<< /D
[ 183 0 R /XYZ 313 468 null
]
>>
endobj
46 0 obj
<< /D
[ 1320 0 R /XYZ 131 139 null
]
>>
endobj
47 0 obj
<< /D
[ 354 0 R /XYZ 313 520 null
]
>>
endobj
48 0 obj
<< /Rect
[ 173.160000 390 184.020000 401.220000
] /Dest (G1038074) /Subtype /Link /Border
[ 0 0 0
] /Type /Annot
>>
endobj
49 0 obj
<< /Rect
[ 365.280000 225.900000 445.140000 235.620000
] /Subtype /Link /A
<< /S /URI /URI (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=12772943)
>> /Border
[ 0 0 0
] /Type /Annot
>>
endobj
50 0 obj
<< /Rect
[ 278.520000 594.660000 296.100000 604.380000
] /Subtype /Link /A
<< /S /URI /URI (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=11590392)
>> /Border
[ 0 0 0
] /Type /Annot
>>
endobj
51 0 obj
<< /D
[ 789 0 R /XYZ 521 466 null
]
>>
endobj
52 0 obj
<< /D
[ 572 0 R /XYZ 340 597 null
]
>>
endobj
53 0 obj
<< /Count 18 /First 231 0 R /Title (Root) /Last 390 0 R
>>
endobj
54 0 obj
<< /Rect
[ 55.140000 492.660000 84.600000 501.900000
] /Subtype /Link /A
<< /S /URI /URI (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=12796198)
>> /Border
[ 0 0 0
] /Type /Annot
>>
endobj
55 0 obj
<< /Limits
[ (I1.1025614) (I1.1039732)
] /Names
[ (I1.1025614) 1707 0 R (I1.1025641) 19 0 R (I1.1025643) 19 0 R (I1.1025645) 19 0 R (I1.1025647) 19 0 R (I1.1025649) 19 0 R (I1.1025651) 19 0 R (I1.1025653) 19 0 R (I1.1025655) 19 0 R (I1.1025657) 19 0 R (I1.1025659) 19 0 R (I1.1025661) 19 0 R (I1.1025663) 19 0 R (I1.1025665) 19 0 R (I1.1025759) 518 0 R (I1.1025761) 518 0 R (I1.1025763) 518 0 R (I1.1025802) 1005 0 R (I1.1025830) 1167 0 R (I1.1025832) 1167 0 R (I1.1025871) 76 0 R (I1.1025873) 76 0 R (I1.1025875) 76 0 R (I1.1025877) 76 0 R (I1.1025927) 411 0 R (I1.1025929) 411 0 R (I1.1025968) 731 0 R (I1.1026014) 893 0 R (I1.1026056) 1059 0 R (I1.1026058) 1059 0 R (I1.1026060) 1059 0 R (I1.1026062) 1059 0 R (I1.1032498) 1699 0 R (I1.1032665) 133 0 R (I1.1032839) 303 0 R (I1.1033022) 457 0 R (I1.1033224) 617 0 R (I1.1033370) 778 0 R (I1.1033668) 946 0 R (I1.1033926) 1111 0 R (I1.1034100) 1269 0 R (I1.1034302) 1433 0 R (I1.1034495) 1593 0 R (I1.1034632) 8 0 R (I1.1034944) 192 0 R (I1.1035218) 353 0 R (I1.1035476) 508 0 R (I1.1035668) 671 0 R (I1.1036099) 831 0 R (I1.1036310) 997 0 R (I1.1036503) 1159 0 R (I1.1036761) 1319 0 R (I1.1037038) 1483 0 R (I1.1037202) 1640 0 R (I1.1037702) 65 0 R (I1.1037988) 244 0 R (I1.1038134) 403 0 R (I1.1038324) 560 0 R (I1.1038622) 721 0 R (I1.1038768) 885 0 R (I1.1039017) 1049 0 R (I1.1039275) 1210 0 R (I1.1039529) 1372 0 R (I1.1039732) 1535 0 R
]
>>
endobj
56 0 obj
<< /D
[ 89 0 R /XYZ 531 633 null
]
>>
endobj
57 0 obj
<< /D
[ 391 0 R /XYZ 313 132 null
]
>>
endobj
58 0 obj
<< /Rect
[ 279.300000 154.980000 290.100000 166.200000
] /Dest (G1034921) /Subtype /Link /Border
[ 0 0 0
] /Type /Annot
>>
endobj
59 0 obj
<< /Rect
[ 313.080000 676.380000 411.600000 684.900000
] /Subtype /Link /A
<< /S /URI /URI (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=11707753)
>> /Border
[ 0 0 0
] /Type /Annot
>>
endobj
60 0 obj
<< /Rect
[ 443.940000 305.640000 554.040000 315.420000
] /Subtype /Link /A
<< /S /URI /URI (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=12028122)
>> /Border
[ 0 0 0
] /Type /Annot
>>
endobj
61 0 obj
<< /D
[ 448 0 R /XYZ 446 211 null
]
>>
endobj
62 0 obj
<< /D
[ 919 0 R /XYZ 342 303 null
]
>>
endobj
63 0 obj
<< /Rect
[ 115.800000 354.720000 126.600000 366
] /Dest (G1052302) /Subtype /Link /Border
[ 0 0 0
] /Type /Annot
>>
endobj
64 0 obj
<< /Rect
[ 408.480000 161.160000 554.040000 170.880000
] /Subtype /Link /A
<< /S /URI /URI (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=9117006)
>> /Border
[ 0 0 0
] /Type /Annot
>>
endobj
65 0 obj
<< /D
[ 1312 0 R /XYZ 342 81 null
]
>>
endobj
66 0 obj
<< /D
[ 1475 0 R /XYZ 396 151 null
]
>>
endobj
67 0 obj
<< /Filter /FlateDecode /Length 6039
>>
stream
x[Ysȑ~_QoKFHl ;a{fNJ؇~(E88 ('. |?ͱ5 vݙ~c_<㙇Çl_jv87oW7my?>龾
?wzi\|ccMz[pz
#{u~l5Ox
˞Mmy/՝NdVq^w`)U{SYv(o-hG,#ӱz
4w4sijcM{vY~`3Sg嬢"QuVIϋ{9tQ8ܤix,c96Fz('ΐlc5yۡ %z )ۍl =EYoJ?Hwbbqw<:Gή9
>t{FfyrWNj/"T]S3nQf;G^D`]k,@
F{TW|[ލ lէzO~8V%O%,]?kTJ,[Bzf#.\8%GYD,UeI:RPBgo֙ɫFjN^{gZ&V[
٢xa0tO{}&$M( rQ]ȑkW~-X1~LVs
!X'=TѶlŠRuW&R +0{D # N|~&yKKM$a2HAUf>,x
8V_b*?奒5RB:OPH0\=n8O~`2:A~y"Bmcû)o P`/ T\g~D5bd!r7tpP(LDᴧ? iniq] wqNR0-%2s0C[jڬ{Wj2O糫|76k@·r$r)c1Vmsm"6^X-L}%8vA #$8hcĘюء#wt;xA:K`9fƬ&*şl_^8"~O@e BM,p%jPN -arIt\%?ʩrT9>@3KX07*s~"KJʵ`ΐ[!lzC<#!b~}?' tΙ=elzEM2UW3݅iLJ@w>`;-m^!P1;#Z|8٥LW(yT1l'2'=c~Ѳ@:Zݪ{voϓHA|2> E
(w"M0s?Ӻn9>Am ߦqmLWAO[u\ϳ?
,U[X^V5<Ob
0Q2Ur
Y%?"5s/kb:
;z&R!p'y}} ~q#)T
ky ^wm( (\ {(ǟ(3~0CᐍqDbvN{h~M~iؽ]r͂u A$\]̡b#vJ͙=2mW0A"Tt?,+:48dZ;pAE2* ~v^_Fl%\Qap|oB5xJ
sP3)9q^ݎ߄^,^!oδ˫3YV\lmO릾OT7s4 {~k߱APS\M͛<e%cߘ$[<,]Q^a{\XWUP+J@sV qCd2- (
3mpQURpskp;glcY*1Jf9n^%ZOfcmH6yJQ|TrAE#ANZڡeQŏkM>P@ |atkُBJ,ʿRQuGwqi{ba Oj Mi+uƏ(Gkʼ
V)f~>/FhbFѬN>goO%m=*NN[^o0MD:X. Qв!#Tؿ!,*/l&߿ )=I^}?тHg_^`Q kNyRqPH7LVw 1#_0@ؽh " fSЕCL1y8¡*
®4$Bz<ljJp
0y;Bw=?2%5ucŀ6ŧxrԳ{}&v.#aa< ]a[qj3sG Ngy870[1v>>1KvE&ሑ%V cUK,d%{xr][
eb;/>9.7݄͂>OHA.fMM㒯bKㅰX/LcsGvxg "g#kK9OIҹ9j b]Ewa,Y-U],HB2f}ء芖0΄6VGaq|'&r4UR;xɸ0i^_B.|uZ(5[AX_ij`Fl7o9}Iњkz\umR(w4O'eiWݾԛXv:+\vEʪ3R@ĕ3uobUpth@mf4x6ǚї?r# 3M>j4oaMĕO[B=
r5FoȣB, caR!N_+i@B"0 9Ne TLw =\g#MC$mČ Qvh<kOpORZYrE(MlfIF3[4e
̟vxޚnkKIQ䩯ib\84"6'R@=K'A,B{9`2eBHV
uy|S?~и?LUɄҸ'%HS9<(53dT?c|Y;Q,Ꞅf*JH4Y,l#[~љ"z!? Ռ$E'"I@1чQ~D-bًY]JFuBձKgؑ<纅5c:mn7TљHi*:0zzk>{=4r`רqϾ'&.BCR ]Ȣ,c#οFɶk}9amZ=p [`X2T- f)?|`^aJGXR2{i$ӰEaz"Ns7s~TB?L^=naP0Έz! ,) DjgStGIC\L{*-5r2p*%贠pV
1!BM1ohV:%5څ7J"%*B^{yV#*+ JeLpߢ;UqI'RgԥG9;Oν(EKBUpJJ.XvO
[8TAR 9-M~rEax`ʡ*1dTs5dRF+8xIW?(h:P(
cR
ENy!"2u;% ތ@I#<3EN G驴fi},rF1R)Eu >H~X;υ*9KX2I 'Jiq.Y1*՝nBLn9)+nD(@3E˸J<{VŋR*&M1ukDfv^s_OySX)kX;!<|!??ܾLP^
ha3y2m3M?Ig\A8ݛAT[P7w,BBx@e("C\dl"g\,pJ7jb@-Uے觌j9NIDc؉x]2kO=й:ޯۂyCif#V3[*
?: +Σ =1-Ҭy MgG"yN1J:d5D)o``c(rBc
=jpAu.ڝbn$/K7[,_~40Du"Y2DpJ#ŘEވb