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  1. Research

    Effects of the common polymorphism in the human aldehyde dehydrogenase 2 (ALDH2) gene on the lung

    Aldehyde dehydrogenases (ALDHs) play a major role in detoxification of aldehydes. High expression of ALDHs is a marker for stem cells of many organs including the lungs. A common polymorphism in ALDH2 gene (ALDH2...

    Aoi Kuroda, Ahmed E. Hegab, Gao Jingtao, Shuji Yamashita, Nobuyuki Hizawa, Tohru Sakamoto, Hideyasu Yamada, Satoshi Suzuki, Makoto Ishii, Ho Namkoong, Takanori Asakura, Mari Ozaki, Hiroyuki Yasuda, Junko Hamamoto, Shizuko Kagawa, Kenzo Soejima…

    Respiratory Research 2017 18:69

    Published on: 21 April 2017

  2. Research

    Outcomes after early and delayed rehabilitation for exacerbation of chronic obstructive pulmonary disease: a nationwide retrospective cohort study in Japan

    The effectiveness of early pulmonary rehabilitation (PR) for exacerbation of chronic obstructive pulmonary disease (COPD) remains controversial. The present study aimed to compare the outcomes between early an...

    Hiroki Matsui, Taisuke Jo, Kiyohide Fushimi and Hideo Yasunaga

    Respiratory Research 2017 18:68

    Published on: 21 April 2017

  3. Review

    Understanding the impact of symptoms on the burden of COPD

    Chronic obstructive pulmonary disease (COPD) imposes a substantial burden on individuals with the disease, which can include a range of symptoms (breathlessness, cough, sputum production, wheeze, chest tightne...

    Marc Miravitlles and Anna Ribera

    Respiratory Research 2017 18:67

    Published on: 21 April 2017

  4. Research

    Monitoring mandibular movements to detect Cheyne-Stokes Breathing

    The patterns of mandibular movements (MM) during sleep can be used to identify increased respiratory effort periodic large-amplitude MM (LPM), and cortical arousals associated with “sharp” large-amplitude MM (...

    Jean-Benoît Martinot, Jean-Christian Borel, Nhat-Nam Le-Dong, Hervé Jean-Pierre Guénard, Valerie Cuthbert, Philip E. Silkoff, David Gozal and Jean-Louis Pepin

    Respiratory Research 2017 18:66

    Published on: 20 April 2017

  5. Research

    Protein antigen of bird-related hypersensitivity pneumonitis in pigeon serum and dropping

    Avian antigen is a common cause of hypersensitivity pneumonitis (HP). Inhalation challenge with pigeon serum and pigeon dropping extract (PDE) elicits a hypersensitivity reaction in patients with bird-related ...

    Tsuyoshi Shirai, Haruhiko Furusawa, Asuka Furukawa, Yuki Ishige, Keisuke Uchida, Yasunari Miyazaki, Yoshinobu Eishi and Naohiko Inase

    Respiratory Research 2017 18:65

    Published on: 20 April 2017

  6. Research

    Computational modeling of airway instability and collapse in tracheomalacia

    Tracheomalacia (TM) is a condition of excessive tracheal collapse during exhalation. Both acquired and congenital forms of TM are believed to result from morphological changes in cartilaginous, fibrous and/or ...

    Scott J. Hollister, Maximilian P. Hollister and Sebastian K. Hollister

    Respiratory Research 2017 18:62

    Published on: 19 April 2017

  7. Research

    Short-term exposure to PM2.5 and vanadium and changes in asthma gene DNA methylation and lung function decrements among urban children

    Both short and long-term exposure to traffic-related air pollutants have been associated with asthma and reduced lung function. We hypothesized that short-term indoor exposure to fine particulate matter <2.5 μ...

    Kyung Hwa Jung, David Torrone, Stephanie Lovinsky-Desir, Matthew Perzanowski, Joshua Bautista, Jacqueline R. Jezioro, Lori Hoepner, Jamie Ross, Frederica P. Perera, Steven N. Chillrud and Rachel L. Miller

    Respiratory Research 2017 18:63

    Published on: 19 April 2017

  8. Research

    Interleukin-6 displays lung anti-inflammatory properties and exerts protective hemodynamic effects in a double-hit murine acute lung injury

    Interleukin 6 (IL-6) is a predictive factor of poor prognosis in patients with acute respiratory distress syndrome (ARDS). However, its acute pulmonary hemodynamic effects and role in lung injury have not been...

    Guillaume Voiriot, Keyvan Razazi, Valérie Amsellem, Jeanne Tran Van Nhieu, Shariq Abid, Serge Adnot, Armand Mekontso Dessap and Bernard Maitre

    Respiratory Research 2017 18:64

    Published on: 19 April 2017

  9. Research

    Telomere shortening and accelerated aging in COPD: findings from the BODE cohort

    Chronic Obstructive Pulmonary Disease (COPD) may be associated with accelerated aging. Telomere shortening is a biomarker of aging. Cross-sectional studies describe shorter telomeres in COPD compared with matc...

    Córdoba-Lanús Elizabeth, Cazorla-Rivero Sara, Espinoza-Jiménez Adriana, Juan P. de-Torres, Pajares María-José, Aguirre-Jaime Armando, Celli Bartolomé and Casanova Ciro

    Respiratory Research 2017 18:59

    Published on: 13 April 2017

  10. Research

    Determining the presence of asthma-related molecules and salivary contamination in exhaled breath condensate

    Researchers investigating lung diseases, such as asthma, have questioned whether certain compounds previously reported in exhaled breath condensate (EBC) originate from saliva contamination. Moreover, despite ...

    Charmion Cruickshank-Quinn, Michael Armstrong, Roger Powell, Joe Gomez, Marc Elie and Nichole Reisdorph

    Respiratory Research 2017 18:57

    Published on: 12 April 2017

  11. Research

    Characterisation of a murine model of the late asthmatic response

    The incidence of asthma is increasing at an alarming rate. While the current available therapies are effective, there are associated side effects and they fail to adequately control symptoms in all patient sub...

    Katie Baker, Kristof Raemdonck, Robert J. Snelgrove, Maria G. Belvisi and Mark A. Birrell

    Respiratory Research 2017 18:55

    Published on: 11 April 2017

  12. Research

    ABCB1 and ABCG2 drug transporters are differentially expressed in non-small cell lung cancers (NSCLC) and expression is modified by cisplatin treatment via altered Wnt signaling

    Lung cancer (LC) is still the most common cause of cancer related deaths worldwide. Non-small cell lung cancer (NSCLC) accounts for 85% of all LC cases but is not a single entity. It is now accepted that, apar...

    M. Vesel, J. Rapp, D. Feller, E. Kiss, L. Jaromi, M. Meggyes, G. Miskei, B. Duga, G. Smuk, T. Laszlo, I. Karner and J.E. Pongracz

    Respiratory Research 2017 18:52

    Published on: 24 March 2017

  13. Research

    Altered mTOR and Beclin-1 mediated autophagic activation during right ventricular remodeling in monocrotaline-induced pulmonary hypertension

    Right ventricular structure and function is a major predictor of outcomes in pulmonary hypertension (PH), yet the underlying mechanisms remain poorly understood. Growing evidence suggests the importance of aut...

    Yan Deng, Weifeng Wu, Shenglan Guo, Yuming Chen, Chang Liu, Xingcui Gao and Bin Wei

    Respiratory Research 2017 18:53

    Published on: 24 March 2017

  14. Research

    Caffeine modulates glucocorticoid-induced expression of CTGF in lung epithelial cells and fibroblasts

    Although caffeine and glucocorticoids are frequently used to treat chronic lung disease in preterm neonates, potential interactions are largely unknown. While anti-inflammatory effects of glucocorticoids are w...

    Markus Fehrholz, Kirsten Glaser, Christian P. Speer, Silvia Seidenspinner, Barbara Ottensmeier and Steffen Kunzmann

    Respiratory Research 2017 18:51

    Published on: 23 March 2017

  15. Research

    Cigarette smoke challenges bone marrow mesenchymal stem cell capacities in guinea pig

    Cigarette smoke (CS) is associated with lower numbers of circulating stem cells and might severely affect their mobilization, trafficking and homing. Our study was designed to demonstrate in an animal model of...

    Olga Tura-Ceide, Borja Lobo, Tanja Paul, Raquel Puig-Pey, Núria Coll-Bonfill, Jéssica García-Lucio, Valérie Smolders, Isabel Blanco, Joan A. Barberà and Víctor I. Peinado

    Respiratory Research 2017 18:50

    Published on: 23 March 2017

  16. Research

    Interaction of CD14 haplotypes and soluble CD14 on pulmonary function in agricultural workers

    Agricultural environments are contaminated with organic dusts containing bacterial components. Chronic inhalation of organic dusts is implicated in respiratory diseases. CD14 is a critical receptor for gram-ne...

    Tricia D. LeVan, Lynette M. Smith, Art J. Heires, Ted R. Mikuls, Jane L. Meza, Lisa A. Weissenburger-Moser and Debra J. Romberger

    Respiratory Research 2017 18:49

    Published on: 16 March 2017

  17. Letter to the Editor

    Increased IL-17RA and IL-17RC in End-Stage COPD and the Contribution to Mast Cell Secretion of FGF-2 and VEGF

    Mast cells are accumulated in advanced chronic obstructive pulmonary disease (COPD), and interleukin (IL)-17 signaling plays a role in disease progression. The expression, localization and functional relevance...

    Abraham B. Roos, Michiko Mori, Harpreet K. Gura, Axel Lorentz, Leif Bjermer, Hans Jürgen Hoffmann, Jonas S. Erjefält and Martin R. Stampfli

    Respiratory Research 2017 18:48

    Published on: 15 March 2017

  18. Letter to the Editor

    Chronic hypoxia aggravates monocrotaline-induced pulmonary arterial hypertension: a rodent relevant model to the human severe form of the disease

    Pulmonary arterial hypertension (PAH) is a severe form of pulmonary hypertension that combines multiple alterations of pulmonary arteries, including, in particular, thrombotic and plexiform lesions. Multiple-p...

    Florence Coste, Christelle Guibert, Julie Magat, Emma Abell, Fanny Vaillant, Mathilde Dubois, Arnaud Courtois, Philippe Diolez, Bruno Quesson, Roger Marthan, Jean-Pierre Savineau, Bernard Muller and Véronique Freund-Michel

    Respiratory Research 2017 18:47

    Published on: 14 March 2017

  19. Research

    Combination of glycopyrronium and indacaterol inhibits carbachol-induced ERK5 signal in fibrotic processes

    Airway fibrosis is one of the pathological features of chronic obstructive pulmonary disease (COPD), and recent studies revealed that acetylcholine plays an important role in the development of airway remodeli...

    Yukiko Namba, Shinsaku Togo, Miniwan Tulafu, Kotaro Kadoya, Kumi Yoneda Nagahama, Hikari Taka, Naoko Kaga, Akira Orimo, Xiangde Liu and Kazuhisa Takahashi

    Respiratory Research 2017 18:46

    Published on: 11 March 2017

  20. Research

    Densitometric and local histogram based analysis of computed tomography images in patients with idiopathic pulmonary fibrosis

    Prior studies of clinical prognostication in idiopathic pulmonary fibrosis (IPF) using computed tomography (CT) have often used subjective analyses or have evaluated quantitative measures in isolation. This st...

    Samuel Y. Ash, Rola Harmouche, Diego Lassala Lopez Vallejo, Julian A. Villalba, Kris Ostridge, River Gunville, Carolyn E. Come, Jorge Onieva Onieva, James C. Ross, Gary M. Hunninghake, Souheil Y. El-Chemaly, Tracy J. Doyle, Pietro Nardelli, Gonzalo V. Sanchez-Ferrero, Hilary J. Goldberg, Ivan O. Rosas…

    Respiratory Research 2017 18:45

    Published on: 7 March 2017

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